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Study focus is on lung cancer, pilot studies have been conducted on COPD and pulmonary embolism.

Papers and conference proceeding can be found below.

Improving lung cancer screening results

At the ERS Conference in Madrid (September 28 – October 2, 2019), Sharina Kort (MST, Enschede, the Netherlands) presented clinical study results on diagnosing lung cancer using the Aeonose:

  1. Improving lung cancer diagnosis from exhaled-breath analysis by adding clinical parameters to the artificial neural network (oral presentation)
  2. Combining exhaled-breath analysis data with clinical parameters to improve the diagnosis of lung cancer (poster presentation)

Combining the electronic nose data and easily-available clinical parameters, she obtained a sensitivity of 96% and a negative predictive value of 93%. Nice results!

Multi-centre prospective study on lung cancer

Electronic nose technology using the Aeonose™ can play an important role in rapidly excluding lung cancer due to the high negative predictive value for various types of lung cancer. Next step will be to find out if the Aeonose™ can be used for population screening on lung cancer.

The article ‘Multi-centre prospective study on diagnosing subtypes of lung cancer by exhaled-breath analysis’ is now available online.

Using this link, you get 50 days’ free access to the article (until November 28, 2018). No sign up, registration or fees are required.

Presentations on European Respiratory Society (ERS)

At the International Congress of the European Respiratory Society (ERS), held in Paris from 15-19 September 2018, the following results on clinical Aeonose studies were presented:

  • Sharina Kort (Enschede, Netherlands), Mayke Tiggeloven, Marjolein Brusse-Keizer, Hugo Schouwink, Frans De Jongh, Emanuel Citgez, Jan Willem Gerritsen, Job Van Der Palen, Detecting subtypes of non-small cell lung cancer by electronic nose. (PA1761)
  • Sharina Kort (Enschede, Netherlands), Marjolein Brusse-Keizer, Hugo Schouwink, Frans De Jongh, Emanuel Citgez, Jan Willem Gerritsen, Job Van Der Palen, Detection of small cell lung cancer by electronic nose. (PA1762)
  • Ekaterina Krauss (Giessen, Germany), Jana Zoelitz, Jasmin Wagner, Guillermo Barretto, Maria Degen, Werner Seeger, Andreas Guenther, The use of electronic nose technology for the detection of Lung Cancer (LC): analysis of exhaled volatile compounds by Aeonose® (PA1758)
  • Michiel Bannier (Maastricht, Netherlands), Kim Van De Kant, Quirijn Jobsis, Edward Dompeling, Feasibility and diagnostic accuracy of an electronic nose in children with asthma and cystic fibrosis (OA338)
  • Luisa Quesada (Brookline, United States of America), Sergio Poli De Frías, Gessica Di Toro, Emines Salas, Ana Gutierrez, Jessica Bello, Isabel Tovar, Maria España, Heriberto Perez, Julian Villalba, Marlene Villalon, Jacobus De Waard, Late Breaking Abstract – An Electronic Nose as a screening tool for childhood Tuberculosis (PA4757)

We’re Losing the Fight’: Tuberculosis Batters a Venezuela in Crisis

Article Aeonose project Venezuela

Tuberculosis (TB) is the world’s deadliest infectious disease, and a top ten cause of death worldwide. Each year, almost 2 million people die from TB. Venezuela is one of the high burden countries with devastating consequences. In Caracas, a medical team (PI: Dr. Jacobus de Waard, mentioned in the NYT-article) is conducting a study for fast TB-screening using an electronic nose (‘Aeonose’) for exhaled-breath analysis. Improved treatment regimes and diagnostics are urgently needed!

Paper on data analysis Aeonose published

Aeonose, Journal of breath research
Kort S, Brusse-Keizer M, Gerritsen JW, Van der Palen J. ‘Data analysis of electronic nose technology in lung cancer: Generating prediction models by means of Aethena’, Journal of Breath Research, vol. 11, nr 2, June 2017.

ERS conference proceedings Milan 2017

Kort S, Brusse-Keizer M, Schouwink JH, Gerritsen JW, van der Palen J, ‘Detection of non-small cell lung cancer by an electronic nose’, ERS-conference, Milano, September 2017.

Fabius TM, Van Leuteren RW, Gerritsen JW, Van der Palen J, De Jongh FHC, Eijsvogel MMM, ‘Acute pulmonary embolism: a specific scent?’ ERS-conference, Milano, September 2017.

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