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Diagnosing gastrointestinal illnesses using fecal headspace volatile organic compounds


fecal VOC analysis with Aetholab

“In our own experience, we used the Aetholab, a commercial electronic nose device (The eNose Company, Zutphen, Netherlands) in a preliminary study of 20 C. difficile PCR-positive stool and 53 C. difficile PCR-negative stool. In a similar approach using an artificial neural network for pattern recognition, we were able to classify the stool with 80% sensitivity, 85% specificity, and 84% accuracy.”

46th World Conference on Lung Health

At the 46th World Conference on Lung Health, Cape Town, South Africa (December 2-6, 2015), results from two Aeonose studies on TB were presented:

EP-138-04: Diagnosis of pulmonary and extra-pulmonary tuberculosis in Paraguay using the electronic nose (Paranose study) by R. Coronel et al,

86 participants were evaluated in 2015, 41 patients suffered from pulmonary TB and 45 were healthy controls. Preliminary analyses show sensitivity of 93% and specificity of 89 %.
A paper is in preparation.

EP-212-0: A new tuberculosis-screening tool: a hand-held electronic nose. A cross-sectional field study in Indonesia by A.M. Saktiawati et al.

87 participants from 5 groups (20 TB patients, 20 TB suspects who were later diagnosed as non TB, 20 non-TB patients, 20 healthy matched controls, and 7 MDR-TB patients) have been investigated showing a sensitivity of 92% and a specificity of 88%. More participants are being included.


TB study in Venezuela has started!

Recently, a study has started for evaluating the Aeonose for diagnosing tuberculosis in the Warao Amerindian population in Venezuela. This population has a high adult and pediatric TB prevalence (comparable to epidemic regions in Africa). At the same time, HIV prevalence is high as well among adults in some villages (up to 20%).

The study is being coordinated by Dr. Jacobus de Waard, Head of the Tuberculosis Laboratory, Universidad Central de Venezuela.

In December 2014, the study was mentioned in a local newspaper in Caracas, Venezuela.


After developing a calibration model for TB in Venezuela, the Aeonose will be evaluated during a blind study.

TB study in Paraguay has started!

A TB study focusing on extra-pulmonary tuberculosis has just started at Instituto de Enfermedades Respiratorias y del Ambiente (INERAM) in Asuncion, Paraguay.

The study is being coordinated by Dr Cecile Magis and Dr Jan-Bart Yntema from Radboud University, Nijmegen, The Netherlands.

First, they will include pulmonary-TB patients and healthy controls in order to build a TB-model for Paraguay. It is important to know if this TB-model differs from models being recorded elsewhere in the world. Next, they will include extra-pulmonary TB patients as mentioned before.

For some impressions, see the pictures below:

Far left: Jan-Bart Yntema. Not in picture: Cecile Magis

Far left: Jan-Bart Yntema. Not in picture: Cecile Magis

Exhaled-breath-test using the Aeonose

Exhaled-breath-test using the Aeonose


Uitzending Business update op Focuz-tv aflevering 116 van 24 mei 2014 laat Dr. Kenneth Kross aan het woord over de behaalde resultaten met de Aeonose in de screening naar Hoofd en Halskanker.

Dr. Kenneth Kross

Dr. Kenneth Kross, item Aeonose start op 18 minuten en 25 seconden

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