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Multi-centre prospective study on lung cancer

Electronic nose technology using the Aeonose™ can play an important role in rapidly excluding lung cancer due to the high negative predictive value for various types of lung cancer. Next step will be to find out if the Aeonose™ can be used for population screening on lung cancer.

The article ‘Multi-centre prospective study on diagnosing subtypes of lung cancer by exhaled-breath analysis’ is now available online.

Using this link, you get 50 days’ free access to the article (until November 28, 2018). No sign up, registration or fees are required.

Presentations on European Respiratory Society (ERS)

At the International Congress of the European Respiratory Society (ERS), held in Paris from 15-19 September 2018, the following results on clinical Aeonose studies were presented:

  • Sharina Kort (Enschede, Netherlands), Mayke Tiggeloven, Marjolein Brusse-Keizer, Hugo Schouwink, Frans De Jongh, Emanuel Citgez, Jan Willem Gerritsen, Job Van Der Palen, Detecting subtypes of non-small cell lung cancer by electronic nose. (PA1761)
  • Sharina Kort (Enschede, Netherlands), Marjolein Brusse-Keizer, Hugo Schouwink, Frans De Jongh, Emanuel Citgez, Jan Willem Gerritsen, Job Van Der Palen, Detection of small cell lung cancer by electronic nose. (PA1762)
  • Ekaterina Krauss (Giessen, Germany), Jana Zoelitz, Jasmin Wagner, Guillermo Barretto, Maria Degen, Werner Seeger, Andreas Guenther, The use of electronic nose technology for the detection of Lung Cancer (LC): analysis of exhaled volatile compounds by Aeonose® (PA1758)
  • Michiel Bannier (Maastricht, Netherlands), Kim Van De Kant, Quirijn Jobsis, Edward Dompeling, Feasibility and diagnostic accuracy of an electronic nose in children with asthma and cystic fibrosis (OA338)
  • Luisa Quesada (Brookline, United States of America), Sergio Poli De Frías, Gessica Di Toro, Emines Salas, Ana Gutierrez, Jessica Bello, Isabel Tovar, Maria España, Heriberto Perez, Julian Villalba, Marlene Villalon, Jacobus De Waard, Late Breaking Abstract – An Electronic Nose as a screening tool for childhood Tuberculosis (PA4757)

Pilot Study: Detection of Gastric Cancer

Pilot Study: Detection of Gastric Cancer From Exhaled Air Analyzed With an Electronic Nose in Chinese Patients

Valérie N. E. Schuermans, MD, PhD1 page1image3832325152, Ziyu Li, MD, PhD2,
Audrey C. H. M. Jongen, MD1,3, Zhouqiao Wu, MD, PhD2,
Jinyao Shi, MD, PhD2, Jiafu Ji, MD, PhD2, and Nicole D. Bouvy, MD, PhD1,3


The aim of this pilot study is to investigate the ability of an electronic nose (e-nose) to distinguish malignant gastric histology from healthy controls in exhaled breath. In a period of 3 weeks, all preoperative gastric carcinoma (GC) patients (n = 16) in the Beijing Oncology Hospital were asked to participate in the study. The control group (n = 28) consisted of family members screened by endoscopy and healthy volunteers. The e-nose consists of 3 sensors with which volatile organic compounds in the exhaled air react. Real-time analysis takes place within the e-nose, and binary data are exported and interpreted by an artificial neuronal network. This is a self-learning computational system. The inclusion rate of the study was 100%. Baseline characteristics differed significantly only for age: the average age of the patient group was 57 years and that of the healthy control group 37 years (P value = .000). Weight loss was the only significant different symptom (P value = .040). A total of 16 patients and 28 controls were included; 13 proved to be true positive and 20 proved to be true negative. The receiver operating characteristic curve showed a sensitivity of 81% and a specificity of 71%, with an accuracy of 75%. These results give a positive predictive value of 62% and a negative predictive value of 87%. This pilot study shows that the e-nose has the capability of diagnosing GC based on exhaled air, with promising predictive values for a screening purpose.

Presentations on DDW Washington

At the Digestive Disease Week (DDW) in Washington DC, held June 2-5 2018, the following topics were presented on Aeonose breath analysis studies:

  1. Liam Zakko, Kavel Visrodia, James Allen, Lori S. Lutzke, Magdalen A. Clemens, Kenneth K. Wang, ‘An electronic-nose device has fair ability to detect non-fasting state via breath sample analysis’,
  2. Kavel Visrodia, Liam Zakko, James Allen, Magdalen A. Clemens, Prasad G. Iyer, Lori S. Lutzke, Kenneth K. Wang, ‘Ongoing development of a screening test for Barrett’s Esophagus using electronic-nose device analysis of exhaled volatile organic compounds’,
  3. Hanneke Huiskamp, Maartje Bartelink, ‘Feasibility of an electronic nose for the detection of Inflammatory Bowel Disease’.

We’re Losing the Fight’: Tuberculosis Batters a Venezuela in Crisis

Article Aeonose project Venezuela

Tuberculosis (TB) is the world’s deadliest infectious disease, and a top ten cause of death worldwide. Each year, almost 2 million people die from TB. Venezuela is one of the high burden countries with devastating consequences. In Caracas, a medical team (PI: Dr. Jacobus de Waard, mentioned in the NYT-article) is conducting a study for fast TB-screening using an electronic nose (‘Aeonose’) for exhaled-breath analysis. Improved treatment regimes and diagnostics are urgently needed!

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